Re: Title: (2009) Caffeine alters proliferation of neuronal precursors in the adult hippocampus

K so wait, there are some things i never got entirely clear. If that's
the case, then what exactly does "while supraphysiological doses (60
mg/kg per day)
increase proliferation of neuronal precursors." mean? Also, are those
figures as is, or is there something I'm missing (because 20mg/kg day)
if you're 70kg would equate to ~1400mg a day of caffeine and that
seems like a horrible much, which seems a bit incongruous since they
consider that low-moderate doses...

Anyone have any insights?

On Sep 15, 3:48 pm, Arky <kenneth.bruskiew...@gmail.com> wrote:
> On Sep 13, 4:48 pm, "Mike L." <cool2bwi...@gmail.com> wrote:
>
> > Does this mean that more than 60mg/kg ofcaffeineincreases
> > neurogenesis, whereas the opposite exists in moderate to high doses?
>
> Nope.
>
> >Caffeineadministration
> >does not affect the expression of early or late markers of neuronal
> >differentiation, or rates of long-term survival. However, neurons
> >induced in response to supraphysiological levels ofcaffeinehave a
> >lower survival rate than control cells; increased proliferation does
> >not yield an increase in long-term neurogenesis.
>
> It might not increase long-term productivity either; at least, it
> didn't for this guy:http://quantifiedself.com/2009/10/the-false-god-of-coffee/

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